TBC1 domain family member 4 (TBC1D4), also designated AS160, can be insulin- and/or AKT1-induced.
Insulin-stimulated phosphorylation is required for GLUT4 translocation.
TBC1D4 may play a role as a GTPase activating protein for proteins in the Rab family.
It is expressed primarily in skeletal muscle and heart, as well as spleen, lymph node and leukocytes.
Defects in the TBC1D4 gene may cause atopic dermatitis (AD), sometimes referred to as eczema, an atopic chronic skin disease.
The skin of affected individuals reacts to irritants or allergens and becomes red, flaky and itchy.
The skin is also more vulnerable to inflammations, and symptoms can grow or disappear over time.
Applications:Suitable for use in Immunofluorescence, Western Blot, Immunohistochemistry.
Other applications not tested.
Recommended Dilution:Western Blot: 1:500-1:1000Immunohistochemistry: 1:50-1:200Immunofluorescence: 1:50-1:200Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid PBS, 0.1% sodium azide, 50% glycerol.
Specificity：Recognizes endogenous levels of TBC1D4, phosphorylated T642. Species Crossreactivity: Human, mouse, rat
Isotype：IgG
Calc Applications Abbrev：IF IHC WB
Calc Crossreactivity：Hu Mo Rt
Immunogen：Synthetic phosphopeptide derived from human TBC1D4 around the phosphorylation site of Threonine 642.
