84-2402-88 ［取扱停止］TAP1 (ABC 17, ABC Transporter MHC 1, ABC17, ABCB 2, ABCB2, Antigen peptide Transporter 1, APT 1, APT1, ATP Binding Cassette sub Family B (MDR/TAP) Member 2, ATP Binding Cassette sub Family B Member 2, ATP Binding Cassette Transporter, ATP-Binding Cassette sub-Family B Member 2, D6S114E, FLJ26666, FLJ41500, Peptide supply Factor 1, Peptide Transporter involved in A ... 226179
84-2402-88 ［取扱停止］TAP1 (ABC 17, ABC Transporter MHC 1, ABC17, ABCB 2, ABCB2, Antigen peptide Transporter 1, APT 1, APT1, ATP Binding Cassette sub Family B (MDR/TAP) Member 2, ATP Binding Cassette sub Family B Member 2, ATP Binding Cassette Transporter, ATP-Binding Cassette sub-Family B Member 2, D6S114E, FLJ26666, FLJ41500, Peptide supply Factor 1, Peptide Transporter involved in A ... 226179
The transporter associated with antigen processing (TAP) is a member of the ATP-binding cassette (ABC) family of transmembrane transporters and is an essential component of the major histocompatability complex (MHC) class I antigen-presenting pathway.
TAP consists of two structurally related subunits, TAP1 and TAP2, that associate into stable dimers and together they form a translocation pore for peptides in the endoplasmic reticulum (ER) membranes.
The functional TAP transporter facilitates the translocation of peptides from the cytosol into the ER lumen for presentation to MHC class I molecules.
Structurally, TAP1 and TAP2 contain an N-terminal transmembrane (TM) region, which together forms the TM pore, and a cytoplasmic peptide-binding pocket.
In addition, the TAP transporter also contains several C-terminal nucleotide-binding domains (NBD), which bind and hydrolyze ATP and in turn, induce structural changes at the membrane to allow the passage of substrates into the ER.
Applications:Suitable for use in Western Blot, Immunohistochemistry.
Other applications not tested.
Recommended Dilution:Western Blot: 1:500-1:2000Immunohistochemistry: 1:50-1:200Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid PBS, 0.1% sodium azide, 50% glycerol.
Specificity：Recognizes endogenous levels of TAP1. Species Crossreactivity: Human
Isotype：IgG
Calc Applications Abbrev：IHC WB
Calc Crossreactivity：Hu
Immunogen：Recombinant full length Human TAP1.
Shelf Life：1year
Swiss Prot Number：Q03518
EU Commodity Code：30021010
商品名：TAP1 (ABC 17, ABC Transporter MHC 1, ABC17, ABCB 2, ABCB2, Antigen peptide Transporter 1, APT 1, APT1, ATP Binding Cassette sub Family B (MDR/TAP) Member 2, ATP Binding Cassette sub Family B Member 2, ATP Binding Cassette Transporter, ATP-Binding Cassette sub-Family B Member 2, D6S114E, FLJ26666, FLJ41500, Peptide supply Factor 1, Peptide Transporter involved in Antigen processing 1, Peptide Transporter PSF 1, Peptide Transporter PSF1, Peptide Transporter TAP 1, Peptide Transporter TAP1, PSF 1, PSF-1, PSF1, Really interesting new Gene 4 Protein, RING 4, RING4, TAP 1, TAP1, TAP1*0102N, TAP1_HUMAN, TAP1N, Transporter 1 ATP Binding Cassette sub Family B (MDR/TAP), Transporter 1 ATP Binding Cassette sub Family B, Transporter Associated with Antigen processing, Transporter ATP Binding Cassette major histocompatibility Complex 1, Y3,) 100ul
