The synuclein family members, including alpha-synuclein (also designated NACP for non-beta Amyloid component) and beta-synuclein, are predominantly expressed in the brain and are speculated to be involved in synaptic regulation and neuronal plasticity.
alpha-synuclein is localized to neuronal cell bodies and synapses.
alpha-synuclein was first identified as a component of Alzheimer’s disease amyloid plaques.
Abnormal platelet function in Alzheimer’s disease has been demonstrated.
During megakaryocytic differentiation alpha-synuclein has been found to be upregulated, while beta-synuclein is downregulated, indicating that coordinate expression of synucleins may be important during hematopoetic cell differentiation.
A mutant form of alpha-synuclein has been found in patients with early onset Parkinson’s disease.
Applications:Suitable for use in Western Blot.
Other applications not tested.
Recommended Dilution:Western Blot: 1:500-1:1000Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid PBS, 0.05% sodium azide, pH 7.2.
Specificity：Recognizes endogenous levels of Synuclein-alpha, phosphorylated Y136. Species Crossreactivity: Human, mouse, rat
Isotype：IgG
Calc Applications Abbrev：WB
Calc Crossreactivity：Hu Mo Rt
Immunogen：Synthetic peptide corresponding to amino acids 120-160 of Human Synuclein-α.
