Synphilin-1 (alpha-synuclein interacting protein, SNCAIP) is a 919 amino acid protein that associates with alpha synuclein and promotes the formation of cytosolic inclusions in neuronal cells.
The synuclein family members, including alpha-synuclein and beta-synuclein, are predominantly expressed in the brain, where they influence synaptic regulation and neuronal plasticity.
Synphilin-1 contains modular protein domains, such as ankyrin-like repeats and a coiled-coil domain.While both alpha-synuclein and synphilin-1 are coexpressed in Lewy bodies of patients with Parkinson’s disease, only mutations in the gene for alpha-synuclein have been determined to confer pathogenicity.
Applications:Suitable for use in Western Blot, Immunohistochemistry.
Other applications not tested.
Recommended Dilution:Western Blot: 1:500-1:1000Immunohistochemistry: 1:50-1:200Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid PBS, 0.05% sodium azide, pH 7.2.
Specificity：Recognizes endogenous levels of Synphilin-1. Species Crossreactivity: Human, mouse, rat
Isotype：IgG
Calc Applications Abbrev：IHC WB
Calc Crossreactivity：Hu Mo Rt
Immunogen：Synthetic peptide corresponding to amino acids 815-867 of Human Synphilin-1.
