84-2401-28　［取扱停止］STEAP3 (1010001D01Rik, Dudlin 2, Dudlin2, Dudulin 2, Dudulin-2, Dudulin2, hpHyde, hTSAP6, Metalloreductase STEAP3, MGC93147, pHyde, Six Transmembrane epithelial Antigen of Prostate 3, Six Transmembrane Prostate Protein 3, Six-Transmembrane epithelial Antigen of Prostate 3, STEA 3, STEA3, STEAP 3, STEAP Family Member 3, STEAP Family Member 3 metalloreductase, STEAP ...　226096

特徴

• pHyde has a potential role as a tumor suppressor by inducing caspase-3-mediated apoptosis and stimulating p53 expression.
• A dose-dependent increase in caspase-3 activity is observed in transduced pHyde DU145 cells.
• Furthermore, caspase-3 may be necessary for pHyde-mediated apoptosis.
• The pHyde gene may upregulate the apoptosis pathway and thus have a potential application in cancer gene therapy.
• Recombinant pHyde inhibits the growth of human prostate cancer cell lines DU145 and LNCaP in vitro.
• DU145 tumors may be reduced significantly in vivo when nude mice are injected with recombinant pHyde.
• pHyde also has a demonstrated growth inhibitory effect on human breast cancer cells.
• This suggests that pHyde may have a role in inhibiting different tumor types.
• Applications:Suitable for use in Western Blot, Immunohistochemistry.
• Other applications not tested.
• Recommended Dilution:Western Blot: 1:500-1:2000Immunohistochemistry: 1:50-1:200Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.