84-2399-13　［取扱停止］SPAG9 (C-Jun-amino-Terminal Kinase-interacting Protein 4, JIP-4, JNK-interacting Protein 4, Cancer/Testis Antigen 89, CT89,Human lung Cancer Oncogene 6 Protein, HLC-6, JNK-Associated Leucine-Zipper Protein, JLP, Mitogen-Activated Protein Kinase 8-interacting Protein 4, Proliferation-inducing Protein 6, Protein highly expressed in Testis, PHET, Sperm Surface Protei ...　225989

特徴

• JIP-4 (C-jun-amino-terminal kinase-interacting protein 4, Mitogen-activated protein kinase 8-interacting protein 4, Sunday driver 1) is a 1,321 amino acid protein encoded by the human gene SPAG9.
• It contains a large N-terminal extracellular domain, a short transmembrane helical domain, and a cytoplasmic domain.
• There are 6 N-glycosylation sites, several phosphorylation sites for cAMP/cGMP-dependent protein kinase, protein kinase C, and casein kinase II, and 10 putative myristoylation sites.
• There is also a leucine zipper motif, with 6 leucine repeats, that may aid in dimerization since there is no upstream basic domain characteristic of DNA binding proteins.
• The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module.
• JIP-4 is a cytoplasmic, perinuclear protein that has eight known isoforms whose expression varies by tissue and disease state.
• Applications:Suitable for use in Western Blot.
• Other applications not tested.
• Recommended Dilution:Western Blot: 1:500-1:1000Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.