Sorbitol Dehydrogenase, also known as L-iditol 2-dehydrogenase, SORD or SORD1, is a 357 amino acid member of the zinc-containing alcohol dehydrogenase family.
Widely expressed with highest expression in kidney and in the lens of the eye, Sorbitol Dehydrogenase enzymatically catalyzes the zinc-dependent interconversion of polyols, such as such as sorbitol and xylitol, to their respective ketoses.
These reactions require NAD+ as an oxidizing agent and, together with Aldose Reductase, they comprise the sorbitol pathway that is involved in sugar production.
Sorbitol Dehydrogenase deficiency leads to defects in this pathway and a subsequent accumulation of sorbitol within the cell, a condition that may be associated with diabetic complications such as cataracts and microvascular problems.
Applications:Suitable for use in Western Blot, Immunohistochemistry.
Other applications not tested.
Recommended Dilution:Western Blot: 1:500-1:2000Immunohistochemistry: 1:50-1:200Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid PBS, 0.1% sodium azide, 50% glycerol.
Specificity：Recognizes endogenous levels of SORD. Species Crossreactivity: Human, mouse, rat
