84-2398-45　［取扱停止］SNRPD3 (Small Nuclear Ribonucleoprotein Sm D3, Sm-D3, snRNP Core Protein D3, SNRPD3) 50ul　225955

特徴

• U1, U2, U4, U5, U6 and U7 are small nuclear ribonucleoproteins (snRNPs) that comprise the spliceosome in eukaryotes.
• Each UsnRNP contains common Sm proteins B/B', D1, D2, D3, E, F and G.
• The Sm proteins pair up as D1-D2, B/B'-D3 and E-F-G to form RNA-free hetero-oligomers in the cytoplasm.
• Sm proteins aid in the cytoplasmic construction of the UsnRNPs by binding to a conserved Sm site on UsnRNA and forming a stable snRNP core complex.
• Sm D1, D2 and D3 are present in U1, U2, U4/5 and U5 but not U7 snRNPs in human and mouse cells.
• U7 snRNPs contain Lsm10, an Sm D1-like protein.
• Autoantibodies produced in patients suffering from systemic lupus erythematosus react predominantly with Sm B/B', D1 and D3.
• The major linear epitope of these autoantibodies includes the C-terminal RG dipeptide repeats found in Sm D1 and D3.
• Applications:Suitable for use in Western Blot.
• Other applications not tested.
• Recommended Dilution:Western Blot: 1:500-1:1000Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.