The sodium-dependent multivitamin transporter (SMVT) is a 635 amino acid protein that belongs to the sodium-coupled glucose transporter family.
SMVT contains 12 putative transmembrane domains with the N and C termini both facing towards the cytoplasm.
Its function is to transport the essential vitamins pantothenate, biotin, and the metabolite lipoate into cells of various human tissues.
Biotin, also known as vitamin B6, is important in synthesizing fatty acids gluconeogenesis, and metabolizing leucine, while pantothenate, or vitamin B5, is critical in the metabolism and synthesis of carbohydrates, proteins, and fats.
Lipoate is involved in oxidative metabolism.
SMVT uses a specialized carrier-mediated system to take up these vitamins and metabolites into the cells.
This process is active and uses energy from the transmembrane sodium ion gradient as well as the membrane potential.
Applications:Suitable for use in Western Blot, Immunohistochemistry.
Other applications not tested.
Recommended Dilution:Western Blot: 1:500-1:2000Immunohistochemistry: 1:50-1:200Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：50ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid PBS, 0.1% sodium azide, 50% glycerol.
Specificity：Recognizes endogenous levels of SLC5A6. Species Crossreactivity: Human
