SKIV2L2 (superkiller viralicidic activity 2-like 2) is a 1,042 amino acid protein that belongs to the helicase family and the SKI2 subfamily.
The SKIV2L2 protein localizes to nucleus, contains one helicase ATP-binding domain and one helicase C-terminal domain.
SKIV2L2 is identified in the spliceosome C complex and may be involved in pre-mRNA splicing.
SKIV2L2 is associated with the RNA exosome complex and involved in the 3' processing of the 7S pre-RNA to the mature 5.8S rRNA.
The SKIV2L2 gene is conserved in chimpanzee, canine, bovine, mouse, rat, chicken, zebrafish, fruit fly, mosquito, C.
elegans, S.
pombe, S.
cerevisiae, K.
lactis, E.
gossypii, M.
grisea, N.
crassa, A.
thaliana and rice, and maps to human chromosome 5q11.2.
A mutation in SKIV2L2 in zebrafish causes defects in cell proliferation, suggesting that SKIV2L2 plays a role in regulating melanoblast proliferation during early stages of melanocyte regeneration.
Applications:Suitable for use in Western Blot, Immunohistochemistry.
Other applications not tested.
Recommended Dilution:Western Blot: 1:500-1:2000Immunohistochemistry: 1:50-1:200Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid PBS, 0.1% sodium azide, 50% glycerol.
Specificity：Recognizes endogenous levels of SKIV2L2 . Species Crossreactivity: Human, mouse, rat
