SWAP (suppressor of white apricot protein homolog), also known as SFRS8 (splicing factor, arginine/serine-rich 8), is the 951 amino acid human homolog of a Drosophilia splicing protein.
Localized to the nucleus, SWAP contains two SURP repeats through which it is thought to mediate splicing events, possibly regulating the alternative splicing of Fibronectin and CD45RC.
SWAP regulates its own expression levels (via control of splicing in its first two introns) and may act in tandem with other arginine/serine-rich splicing factors to control protein expression.
The gene encoding SWAP is located on a region of chromosome 12 that is related to asthma susceptibility, possibly indicating a role for SWAP in the development of asthma.
Multiple isoforms of SWAP exist due to alternative splicing events.
Applications:Suitable for use in Western Blot.
Other applications not tested.
Recommended Dilution:Western Blot: 1:500-1:1000Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：50ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid PBS, 0.05% sodium azide, pH 7.2.
Specificity：Recognizes endogenous levels of SFRS8. Species Crossreactivity: Human, mouse, rat
Isotype：IgG
Calc Applications Abbrev：WB
Calc Crossreactivity：Hu Mo Rt
Immunogen：Synthetic peptide corresponding to amino acids 251-296 of Human SFRS8.
