Huntington's disease (HD), a neurodegenerative disorder characterized by loss of striatal neurons, is caused by an expansion of a polyglutamine tract in the HD protein huntingtin.
This gene encodes a protein belonging to a class of huntingtin interacting proteins characterized by WW motifs.
This protein is a histone methyltransferase that is specific for lysine-36 of histone H3, and methylation of this residue is associated with active chromatin.
This protein also contains a novel transcriptional activation domain and has been found associated with hyperphosphorylated RNA polymerase II.
Applications:Suitable for use in Western Blot, Immunohistochemistry.
Other applications not tested.
Recommended Dilution:Western Blot: 1:500-1:2000Immunohistochemistry: 1:50-1:200Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：50ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid PBS, 0.1% sodium azide, 50% glycerol.
Specificity：Recognizes endogenous levels of SETD2. Species Crossreactivity: Human, mouse, rat
Isotype：IgG
Calc Applications Abbrev：IHC WB
Calc Crossreactivity：Hu Mo Rt
Immunogen：Recombinant full length Human SETD2.
Shelf Life：1year
Swiss Prot Number：Q9BYW2
EU Commodity Code：30021010
商品名：SETD2 (HBP231, HIF 1, HIF-1, HIF1, HIP-1, Histone lysine N Methyltransferase SETD2, Histone-lysine N-Methyltransferase SETD2, hSET2, HSPC069, Huntingtin interacting Protein 1, Huntingtin interacting Protein, Huntingtin interacting Protein B, Huntingtin interacting Protein HYPB, Huntingtin yeast Partner B, Huntingtin-interacting Protein 1, Huntingtin-interacting Protein B, HYPB, KIAA1732, KMT3A, Lysine N Methyltransferase 3A, Lysine N-Methyltransferase 3A, p231HBP, SET Domain Containing 2, SET Domain-Containing Protein 2, SET2, SETD2, SETD2_HUMAN,) 50ul
