The serine proteinase inhibitors (serpins) comprise a superfamily of proteins with a diverse set of functions, including the control of complement activation, blood coagulation, programmed cell death and cell development.
Serpins are secreted glycoproteins that contain a stretch of peptide that mimics a true substrate for a corresponding serine protease.
The most abundant serpins in human plasma are a-1-antitrypsin (AAT) and a-1-antichymotrypsin (AACT).
Other serpin family members include pigment epithelium-derived growth factor (PEDF), human protease nexin 1 (PN-1), protease inhibitor 6 (PI-6), thyroxine-binding globulin precursor (TBG), protease inhibitor 9 (PI-9), serine protease inhibitor 3 (Spi3), plasma protease C1 inhibitor (C1INH), Headpin, SerpinB12, monocyte/neutrophil elastase inhibitor members 1a,1b and 1c (M/NEI) and squamous cell carcinoma antigens 1 and 2 (SCCA1/2).
Antithrombin-III (ATIII) is a crucial serine protease inhibitor that regulates the coagulation cascade in blood and inhibits Thrombin.
Applications:Suitable for use in Western Blot and Immunohistochemistry.
Other applications not tested.
Recommended Dilution:Western Blot: 1:500-1:2000Immunohistochemistry: 1:50-1:200Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：50ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid PBS, 0.09% sodium azide, 50% glycerol.
Specificity：Recognizes endogenous levels of human SERPING1. Species Crossreactivity: mouse and rat
Isotype：IgG
Calc Applications Abbrev：IHC WB
Calc Crossreactivity：Hu Mo Rt
Immunogen：Full length recombinant protein corresponding to human SERPING1 (P05155).
