84-2394-52　［取扱停止］SERPINC1 (Antithrombin, Antithrombin III, Antithrombin-III, AntithrombinIII, AT 3, AT III, AT3, ATIII, MGC22579, Serine (or cysteine) Proteinase Inhibitor clade C (antithrombin) Member 1, Serine cysteine Proteinase Inhibitor clade C Member 1, Serine Proteinase Inhibitor clade C Member 1, Serpin C1, Serpin peptidase Inhibitor clade C (antithrombin) Member 1, SERPINC1) 100ul　225754

特徴

• The serine proteinase inhibitors (serpins) compose a superfamily of proteins with a diverse set of functions, including the control of blood coagulation, complement activation, programmed cell death and development.
• Serpins are secreted glycoproteins that contain a stretch of peptide that mimics a true substrate for a corresponding serine protease.
• Antithrombin III (ATIII), an extracellular plasma protein, is a crucial serine protease inhibitor that regulates the coagulation cascade in blood.
• The inhibitory activity of ATIII is amplified in the presence of heparin.
• ATIII inhibits Thrombin and Factors IXa, Xa and XIa.
• Defects in the gene SERPINC1, which encodes for ATIII, can cause ATIII deficiency, an autosomal dominant disease which is a risk factor for hereditary thrombophilia.
• Applications:Suitable for use in Western Blot, Immunohistochemistry.
• Other applications not tested.
• Recommended Dilution:Western Blot: 1:500-1:2000Immunohistochemistry: 1:50-1:200Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.