The serine proteinase inhibitors (serpins) are a superfamily of proteins with a diverse set of functions, including the control of blood coagulation, complement activation, programmed cell death and development.
The most abundant serpins in human plasma are a 1-antitrypsin (AAT) and a 1-antichymotrypsin (AACT).
AACT (also called A1AC and SERPINA3) is a plasma protease inhibitor synthesized in the liver as a single glycopeptide chain.
In human, the normal serum level of AACT is about one-tenth that of AAT, with which it shares nucleic acid and protein sequence homology.
Both are major acute phase reactants; their concentrations in plasma increase in response to trauma, surgery and infection.
Elevated levels of AACT are widely, but not universally, reported in the cerebrospinal fluid and plasma of AD patients.
Prostate-specific antigen (PSA) and its SDS-stable complex with AACT are in widespread use as markers for the diagnosis of prostate cancer.
AACT deficiency may also be a possible cause of chronic liver disease.
Applications:Suitable for use in Western Blot.
Other applications not tested.
Recommended Dilution:Western Blot: 1:500-1:1000Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：50ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid.
Specificity：Recognizes endogenous levels of SERPINA3. Species Crossreactivity: Human, mouse, rat
Isotype：IgG
Calc Applications Abbrev：WB
Calc Crossreactivity：Hu Mo Rt
Immunogen：A synthetic peptide corresponding to residues in Human SERPINA3
