84-2392-67　［取扱停止］RUVBL1 (49kD TATA box Binding Protein interacting Protein, 49kD TATA box-Binding Protein-interacting Protein, 49kD TBP interacting Protein, 49kD TBP-interacting Protein, 54kD Erythrocyte cytosolic Protein, ECP-54, ECP54, Erythrocyte CYTOSOLIC Protein, 54-KD, INO80 Complex Subunit H, NMP 238, Nuclear Matrix Protein 238, Pontin 52, PONTIN, RuvB like 1, RuvB-like 1, ...　225660

特徴

• Pontin 52 is nuclear matrix protein that is primarily expressed in the nucleus and is also present in the cytoplasm.
• Pontin 52 is expressed in the nucleoplasm of whole cells, but is not present in the nucleoli.
• Pontin 52 is also designated RUVBL1, for E.
• coli RuvB-like 1 protein, or NMP 238, and is the human homolog of rat TIP49.
• Pontin 52 contains an ATPase/helicase motif and may represent a class of cofactors recruited by transcriptional activation domains that function in diverse pathways.
• For instance, in vivo, Pontin 52 is complexed with Myc and Reptin 52, which is a Pontin 52 related protein also designated RUVBL2.
• The interaction of Pontin 52 with Myc is dependent upon a Myc domain essential for oncogenic activity, suggesting that functional Pontin 52 is an essential mediator of Myc oncogenic transformation.
• The gene encoding human Pontin 52 maps to chromosome 3q21.
• Applications:Suitable for use in Western Blot, Immunohistochemistry.
• Other applications not tested.
• Recommended Dilution:Western Blot: 1:500-1:2000Immunohistochemistry: 1:50-1:200Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.