Mammalian ribosomal proteins are encoded by multigene families that consist of processed pseudogenes and one functional intron-containing gene within their coding regions.
Ribosomal Protein L6, also known as RPL6, TAXREB107 or TXREB1, is a 288 amino acid component of the large ribosomal 60S subunit.
Localized to the cytoplasm, Ribosomal Protein L6 binds specifically to domain C of the tax-responsive element (FOXN2) of human T-cell leukemia virus type 1, thereby regulating tax-mediated transcriptional activation.
Ribosomal Protein L6 is upregulated in multi-drug resistant (MDR) gastric cancer cells and is implicated in Noonan syndrome, a congenital genetic condition characterized by impaired blood clotting, short stature and indentation of the chest.
Two isoforms exist due to alternative splicing events.
Applications:Suitable for use in Western Blot, Immunohistochemistry.
Other applications not tested.
Recommended Dilution:Western Blot: 1:500-1:2000Immunohistochemistry: 1:50-1:200Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid PBS, 0.1% sodium azide, 50% glycerol.
Specificity：Recognizes endogenous levels of RPL6. Species Crossreactivity: Human
