U11/U12 snRNP 65K, also known as RBM40 (RNA-binding protein 40), RNPC3 (RNA-binding region-containing protein 3) or RNP, is a 517 amino acid nuclear protein that plays a role in pre-mRNA U12-dependent splicing by the minor spliceosome, ultimately leading to the removal of U12-type introns.
Expressed at highest levels in kidney and pancreas, U11/U12 snRNP 65K is also weakly detected in placenta, heart, brain, lung, liver, thymus, colon, ovary, testis, prostate, spleen and small intestine.
The gene encoding U11/U12 snRNP 65K maps to human chromosome 1, which spans 260 million base pairs, contains over 3,000 genes and comprises nearly 8% of the human genome.
Chromosome 1 houses a large number of disease-associated genes, including those that are involved in familial adenomatous polyposis, Stickler syndrome, Parkinson’s disease, Gaucher disease, schizophrenia and Usher syndrome.
Applications:Suitable for use in Western Blot, Immunohistochemistry.
Other applications not tested.
Recommended Dilution:Western Blot: 1:500-1:2000Immunohistochemistry: 1:50-1:200Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：50ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid PBS, 0.1% sodium azide, 50% glycerol.
Specificity：Recognizes endogenous levels of RNPC3. Species Crossreactivity: Human
