Ribonucleases are ubiquitous enzymes involved in RNA metabolism and are classified in several families on the basis of their structural, catalytic and biological properties.
RNase 13 (ribonuclease, RNase A family, 13), is a 156 amino acid secreted protein encoded by a gene that maps to human chromosome 14q11.2.
Chromosome 14 houses over 700 genes and comprises nearly 3.5% of the human genome.
Chromosome 14 encodes the presinilin 1 (PSEN1) gene, which is one of the three key genes associated with the development of Alzheimer's disease (AD).
The SERPINA1 gene is also located on chromosome 14 and, when defective, leads to the genetic disorder alpha1-antitrypsin deficiency, which is characterized by severe lung complications and liver dysfunction.
Applications:Suitable for use in Western Blot, Immunohistochemistry.
Other applications not tested.
Recommended Dilution:Western Blot: 1:500-1:2000Immunohistochemistry: 1:50-1:200Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid PBS, 0.1% sodium azide, 50% glycerol.
Specificity：Recognizes endogenous levels of RNASE13. Species Crossreactivity: Human
