Retinitis pigmentosa is an inherited progressive disease which is a major cause of blindness in western communities.
It can be inherited as an autosomal dominant, autosomal recessive, or X linked recessive disorder.
In the autosomal dominant form, which comprises about 25% of total cases, ~30% of families have mutations in the gene encoding the rod photoreceptor specific protein rhodopsin.
This is the transmembrane protein which, when photoexcited, initiates the visual transduction cascade.
Defects in this gene are also one of the causes of congenital stationary night blindness.
Vision involves the conversion of light into electrochemical signals that are processed by the retina and subsequently sent to and interpreted by the brain.
The process of converting light to an electrochemical signal begins when the membrane-bound protein, rhodopsin, absorbs light within the retina.
Applications:Suitable for use in Western Blot, Immunohistochemistry.
Other applications not tested.
Recommended Dilution:Western Blot: 1:500-1:1000Immunohistochemistry: 1:50-1:200Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：50ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid PBS, 0.05% sodium azide, pH 7.2.
Specificity：Recognizes endogenous levels of Rhodopsin. Species Crossreactivity: Human, mouse, rat
Isotype：IgG
Calc Applications Abbrev：IHC WB
Calc Crossreactivity：Hu Mo Rt
Immunogen：Synthetic peptide corresponding to amino acids 301-350 of Human Rhodopsin.
