84-2390-29　［取扱停止］RGS20 (Regulator of G-Protein Signaling 20, Gz-selective GTPase-Activating Protein, G(z)GAP, Gz-GAP, Regulator of G-Protein Signaling Z1, Regulator of Gz-selective Protein Signaling 1, RGSZ1, ZGAP1) 50ul　225541

特徴

• The regulators of G protein signaling (RGS) proteins inhibit heterotrimeric G protein signaling.
• RGS proteins work by functioning as GTPase-activating proteins (which increase the GTPase activity of G protein a subunits) thereby driving G proteins into their inactive GDP-bound form.
• RGS20 is expressed exclusively in brain, with highest levels in the caudate nucleus and temporal lobe.
• RGS20 belongs to the RZ subfamily because it is highly selectivie for the az subunit on G proteins.
• However, if protein kinase C phosphorylates the az subunit, the G protein is much less susceptible to RGS20 action.
• RGS20 directly interacts with the microtubule-destabilizing protein SCG10 (superior cervical ganglia, neural specific 10) and blocks its ability to induce microtubule disassmebly.
• Applications:Suitable for use in Western Blot.
• Other applications not tested.
• Recommended Dilution:Western Blot: 1:500-1:1000Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.