Interphotoreceptor retinoid-binding protein (IRBP) is a retinoid and fatty acid binding protein expressed exclusively in the photoreceptor cells of the retina and pinealocytes of the pineal gland.
The gene encoding human IRBP maps to chromosome 10q11.2.
A putative trans-acting complex binds a cis-element in the IRBP promoter and fully activates transcription of the IRBP gene.
Hypomethylation of cysteine residues in the IRBP promoters of bovine and murine photoreceptor cells permits expression of the IRBP gene.
IRBP may be involved in shuttling retinoids between photoreceptors and the retinal pigment epithelium.
IRBP exists as a glycoprotein with a four-fold repeat structure.
Each 300 amino acid repeat contains one A and one B domain corresponding to the first 80 amino acids (A) and the other 220 amino acids (B).
Along with S-antigen and opsin, the antigenic properties of IRBP induce posterior uveitis, which is characterized by the inflammation of the choroid and photoreceptor cell death.
Applications:Suitable for use in Western Blot, Immunohistochemistry.
Other applications not tested.
Recommended Dilution:Western Blot: 1:500-1:2000Immunohistochemistry: 1:50-1:200Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid PBS, 0.1% sodium azide, 50% glycerol.
Specificity：Recognizes endogenous levels of RBP3. Species Crossreactivity: Human
