84-2389-21　［取扱停止］RASSF1 (123F2, Cardiac specific ras association Domain Family 1 Protein, NORE2A, Pancreas specific ras association Domain Family 1 Protein, Ras association Domain Containing Protein 1, Ras association Domain Family 1, Ras association Domain Family 1A, Ras association Domain Family Protein 1, Ras association Domain-Containing Protein 1, Ras association RalGDS/AF6 D ...　225486

特徴

• Potential tumor suppressor.
• Required for death receptor-dependent apoptosis.
• Mediates activation of STK3/MST2 and STK4/MST1 during Fas-induced apoptosis by preventing their dephosphorylation.
• When associated with MOAP1, promotes BAX conformational change and translocation to mitochondrial membranes in response to TNF and TNFSF10 stimulation.
• Isoform A interacts with CDC20, an activator of the anaphase-promoting complex, APC, resulting in the inhibition of APC activity and mitotic progression.
• Inhibits proliferation by negatively regulating cell cycle progression at the level of G1/S-phase transition by regulating accumulation of cyclin D1 protein.
• Isoform C has been shown not to perform these roles, no function has been identified for this isoform.
• Isoform A disrupts interactions among MDM2, DAXX and USP7, thus contributing to the efficient activation of TP53 by promoting MDM2 self-ubiquitination in cell-cycle checkpoint control in response to DNA damage.
• Applications:Suitable for use in Western Blot, Immunohistochemistry.
• Other applications not tested.
• Recommended Dilution:Western Blot: 1:500-1:2000Immunohistochemistry: 1:50-1:200Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.