Retinoic acid-induced protein 3 (RAI3) is a transmembrane G protein-coupled receptor that affects many essential biological processes including embryogenesis,cell growth, differentiation and apoptosis.
RAI3 may also be involved in maintaining homeostasis of epithelial cells.
Retinoic acid receptors directly regulate RAI3 during its transcription in embryonal carcinoma differentiation.
RAI3 expression is upregulated in most tumor cell lines that express mutant p53, suggesting that p53 interacts with the promoter of RAI3 and represses its expression at the beginning of apoptosis.
RAI3 is a potential molecular target for diagnosing breast cancer; selective suppression of signals from RAI3 may have a place in breast cancer treatments.
Applications:Suitable for use in Western Blot.
Other applications not tested.
Recommended Dilution:Western Blot: 1:500-1:1000Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：50ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid PBS, 15mM sodium azide, pH 7.2.
Specificity：Recognizes endogenous levels of RAI3. Species Crossreactivity: Human, mouse, rat
Isotype：IgG
Calc Applications Abbrev：WB
Calc Crossreactivity：Hu Mo Rt
Immunogen：Synthetic peptide corresponding to amino acids 150-200 of Human RAI3.
