The Ras-related superfamily of guanine nucleotide binding proteins includes the R-Ras, Rap, Ral/Rec and Rho/Rab subfamilies.
Increasing data suggests an important role for Rab proteins in either endocytosis or in biosynthetic protein transport.
The process of transporting newly synthesized proteins from the endoplasmic reticulum to various stacks of the Golgi complex and to secretory vesicles involves the movement of carrier vesicles and requires Rab protein function.
Rab proteins are also an integral part of endocytic pathways.
Rab 38, also known as rrGTPbp or NY-MEL-1, is a melanocyte- and lung-specific member of the Rab family of proteins and localizes to the cell membrane, where it is believed to participate in melanosomal transport and docking.
Rab 38 may play an important role in melanogenesis and in the targeting of TRP1, a protein involved in the production of melanin.
A mutation in the gene encoding Rab 38 may result in oculocutaneous albinism (OCA), a condition in which pigment is absent from eye, skin and hair.
Applications:Suitable for use in Western Blot.
Other applications not tested.
Recommended Dilution:Western Blot: 1:500-1:1000Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid PBS, 0.05% sodium azide, pH 7.2.
Specificity：Recognizes endogenous levels of RAB38. Species Crossreactivity: Human, mouse, rat
Isotype：IgG
Calc Applications Abbrev：WB
Calc Crossreactivity：Hu Mo Rt
Immunogen：Synthetic peptide corresponding to amino acids 122-167 of Human RAB38.
