CD155, a member of the immunoglobulin superfamily, acts as the human receptor for poliovirus (PV).
All three serotypes of PV- PV1, 2, and 3- exhibit similar binding to CD155 in both its glycosylated and fully deglycosylated forms, indicating they utilize a common mechanism for cell entry.
Additionally, CD155 undergoes cell-matrix contacts by binding to the matrix protein vitronectin.
Along with the receptor form, three soluble isoforms, alpha beta, and y, also exist in human serum and cerebrospinal fluid, and CD155 mRNAs are highly expressed in liver tissue.
The presence of soluble CD155 reduces polivirus entry mediated by the membrane-bound receptor, implying an important role for these soluble forms in cellular function.
Applications:Suitable for use in Western Blot, Immunohistochemistry.
Other applications not tested.
Recommended Dilution:Western Blot: 1:500-1:2000Immunohistochemistry: 1:50-1:200Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：50ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid PBS, 0.1% sodium azide, 50% glycerol.
Specificity：Recognizes endogenous levels of PVR. Species Crossreactivity: Human
