Protein-Tyrosine Phosphatase Receptor-Type IA-2beta (PTP IA-2beta), alternately known as PTPRN2 or Phogrin, localizes in dense-core secretory vesicles of pancreas islet cells and influences insulin secretion.
The PTP IA-2beta precursor is an autoantigen that contributes to insulin-dependent diabetes mellitus (IDDM).
The autoantigenic epitopes of PTP IA-2beta appear within the cytoplasmic domain of this transmembrane protein.
PTP IA-2beta is present at high levels in brain and pancreas with lower levels in trachea, prostate, stomach and spinal cord.
The human PTPRN2 gene maps to chromosome 7q36.
Northern blot analysis showed that PTPRN2 was expressed as 5.5- and 3.7-kb transcripts primarily in human brain and pancreas.
Three alternative transcript splice variants of this gene encode distinct proteins.
Applications:Suitable for use in Western Blot.
Other applications not tested.
Recommended Dilution:Western Blot: 1:500-1:1000Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：50ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid PBS, 0.05% sodium azide, pH 7.2.
Specificity：Recognizes endogenous levels of PTPRN2. Species Crossreactivity: Human, mouse, rat
Isotype：IgG
Calc Applications Abbrev：WB
Calc Crossreactivity：Hu Mo Rt
Immunogen：Synthetic peptide corresponding to amino acids 248-293 of Human PTPRN2.
