Protein tyrosine phosphatases, or PTPs, are type I transmembrane proteins,membrane-associated proteins or proteins localized in nuclei.
Examples of transmembrane PTPs are LAR, PTPalpha, PTPbeta, PTPγ, PTPδ, PTPε, PTPζ, PTPκand PTPμ.
Transmembrane PTPs play diverse roles in a variety of cellular processes during development and in adult tissues.
PTP IA-2 (PTP insulinoma-associated protein 2), also known as PTPRN, IA2, ICA512 (islet cell antigen 512) or RPTPN, is a receptor-type PTP-like protein containing a transmembrane region, an intracellular PTP-like domain and an extracellular Nterminus.Localizing to secretory granules, PTP IA-2 is exclusively expressed in neuroendocrine cells (including pancreatic islet cells) and is believed to participate in the regulation of secretory granule exocytosis.
PTP IA-2 is anautoantigen and contributes to Insulin-dependent diabetes mellitus (IDDM).
The detection of autoantibodies against PTP IA-2 is commonly used as a diabetes diagnosis marker.
Applications:Suitable for use in Western Blot, Immunohistochemistry.
Other applications not tested.
Recommended Dilution:Western Blot: 1:500-1:2000Immunohistochemistry: 1:50-1:200Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：50ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid PBS, 0.1% sodium azide, 50% glycerol.
Specificity：Recognizes endogenous levels of PTPRN. Species Crossreactivity: Human, mouse, rat
