84-2386-49　［取扱停止］PTPN2 (Protein Tyrosine Phosphatase non Receptor Type 2, PTN2, PTPN 2, PTPN2, PTPT, T Cell Protein Tyrosine Phosphatase, TC PTP, TCellPTP, Tyrosine Protein Phosphatase non Receptor Type 2) 50ul　225345

特徴

• T-cell protein tyrosine phosphatase (TC-PTP) is a non-transmembrane enzyme.
• The noncatalytic domain of TC-PTP is alternatively spliced to generate p45TC, which localizes to the nucleus, and p48TC, which contains a hydrophobic C-terminal tail and localizes to the ER.
• The C-terminal segment of p45TC regulates the activity of the catalytic domain through an intramolecular interaction.
• The p45TC variant of TC-PTP exits the nucleus upon EGF receptor activation and recognizes the EGF receptor and p52Shc cellular substrates.
• The p45TC activity almost completely inhibits the EGF-dependent activation of PI 3-kinase and PKB/Akt.
• In glioblastoma cells, the p45TC variant inhibits the DEGFR-mediated activation of ERK2 and suppresses tumorigenicity in vivo.
• TC-PTP may play a role in lymphoctye signaling and hematopoietic homeostasis.
• TC-PTP negatively regulates JAK1 and JAK3 and TC-PTP-deficient mice display gross defects in the hematopoietic system.
• The gene encoding human TC-PTP maps to chromosome 18.
• Applications:Suitable for use in Western Blot, Immunohistochemistry.
• Other applications not tested.
• Recommended Dilution:Western Blot: 1:500-1:2000Immunohistochemistry: 1:50-1:200Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.