Chromosome 14 contains about 700 genes and 106 million base pairs and makes up about 3.5% of human cellular DNA.
Chromosome 14 encodesthe presinilin 1 (PSEN1) gene,which is one of the three key genes associated with the development of Alzheimer’s disease.
The SERPINA1 gene islocated on chromosome 14 and when defective leadsto the genetic disorder alpha1-antitrypsin deficiency.
This disorder is characterized bysevere lung complications and liver dysfunction.
Notably, the immunoglobulin heavychain locusisfoundon chromosome 14 and has been identified as a fusion with the chromosome 19 encoded protein Bcl-3 in the translocationsfound in a variety of B cellmalignancies.
The PSMC1 gene product has been provisionally designated PSMC1 pending furthercharacterization.
Applications:Suitable for use in Western Blot, Immunohistochemistry.
Other applications not tested.
Recommended Dilution:Western Blot: 1:500-1:2000Immunohistochemistry: 1:50-1:200Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：50ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid PBS, 0.1% sodium azide, 50% glycerol.
Specificity：Recognizes endogenous levels of PSMC1. Species Crossreactivity: Human, mouse, rat
