84-2385-05　［取扱停止］PRRX2 (Paired mesoderm homeobox Protein 2, Paired-Related homeobox Protein 2, PRX-2, PRRX2, PMX2, PRX2) 100ul　225272

特徴

• The paired-class homeobox genes PRX1 and PRX2 are necessary for craniofacial and limb development and are expressed in similar patterns in the cranial mesenchyme, limb buds, axial mesoderm and branchial arches.
• These proteins exhibit different patterns of expression, however, in heart and brain tissue.
• Specifically, PRX1 is expressed in the endocardial cusions, semilunar and atrioventricular valves, whereas PRX2 is initially expressed in a diffuse myocardial pattern and is later expressed in the ventricular septum.
• Furthermore, PRX2 is never expressed in the brain, whereas PRX1 is expressed in the ventral hypothalamus and in the telencephalon.
• Murine mutants lacking PRX1 function demonstrate skeletal defects in the skull, limbs, and vertebral column.
• Mice lacking functional PRX2 alone do not demonstrate skeletal abnormalities, however, PRX1/PRX2 double mutants demonstrate novel abnormalities that are not visualized with the PRX1-deficient mice.
• Transcripts of neither PRX1 nor PRX2 are detected in normal adult rat pulmonary arteries, however vasular disease induces PRX gene expression wherein they colocalize to sites of Tenascin-C expression.
• Applications:Suitable for use in Western Blot.
• Other applications not tested.
• Recommended Dilution:Western Blot: 1:500-1:1000Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.