Endocrine gland-derived vascular endothelial growth factor (EG-VEGF) induces proliferation,migration and fenestration in capillary endothelialcells derived from endocrine glands.
EG-VEGF possesses a HIF-1 binding site; its expression isinduced by hypoxia and restricted to the steroidogenic glands(ovary,testis, adrenal and placenta).
EG-VEGF expression is often complementary to the expression of VEGF,suggesting that these moleculesfunction in a coordinatedmanner.
EG-VEGFis an example of a class of highly specificmitogensthat act to regulate proliferation and differentiation of the vascular endothelium in a tissue-specific manner.
EG-VEGFis expressed largely in one type of tissue and actsselectively on one type of endothelium.
EG-VEGF, possiblythrough binding to a G protein-coupled receptor, resultsin the activation ofMAPK p44/42 and phosphatidylinositol 3-kinase signaling pathways, leading to proliferation,migration and survival of responsive endothelialcells.
Applications:Suitable for use in Western Blot.
Other applications not tested.
Recommended Dilution:Western Blot: 1:500-1:1000Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：50ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid PBS, 0.05% sodium azide, pH 7.2.
Specificity：Recognizes endogenous levels of PROK1. Species Crossreactivity: Human, mouse, rat
Isotype：IgG
Calc Applications Abbrev：WB
Calc Crossreactivity：Hu Mo Rt
Immunogen：A synthetic peptide corresponding to residues in Human PROK1.
