PRODH (proline dehydrogenase), also known as proline oxidase 2 (POX2), is a 516 amino acid protein belonging to the proline oxidase family.
Induced during p53-induced apoptosis, PRODH catalyzes the first step in proline degradation by converting proline to delta-1-pyrroline-5-carboxylate.
Defects in PRODH are the cause of hyperprolinemia type 1, a disorder characterized by elevated serum proline levels.
Defects in PRODH may also be involved in the psychiatric and behavioral phenotypes associated with DiGeorge syndrome.
Localized to the mitochondrion matrix, PRODH is expressed at higher levels in lung, brain and skeletal muscle and expressed at lower levels in heart, liver, kidney and pancreas.
PRODH exists as two isoforms produced by alternative splicing.
Applications:Suitable for use in Western Blot, Immunohistochemistry.
Other applications not tested.
Recommended Dilution:Western Blot: 1:500-1:2000Immunohistochemistry: 1:50-1:200Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid PBS, 0.1% sodium azide, 50% glycerol.
Specificity：Recognizes endogenous levels of PRODH. Species Crossreactivity: Human
