84-2384-71　［取扱停止］PRMT2 (ANM2_HUMAN, EC 2.1.1., histone Arginine N Methyltransferase PRMT2, Histone-Arginine N-Methyltransferase PRMT2, HMT 1, HMT1 (hnRNP Methyltransferase S. cerevisiae) like 1, HMT1, HMT1 hnRNP Methyltransferase like 1, hnRNP Methyltransferase (S. cerevisiae) like 1, hnRNP Methyltransferase like 1, Hrmt1l1, MGC111373, PRMT 2, PRMT2 alpha, prmt2, PRMT2 beta, PRMT2 ...　225255

特徴

• PRMT2 (Protein arginine N-methyltransferase 2) is a 433 amino acid protein encoded by the human gene PRMT2.
• PRMT2 belongs to the protein arginine N-methyltransferase family and contains one SH3 domain.
• The primary function of protein methyltransferases is the post-translational methylation of arginine residues.
• The PRMT family of proteins contains related putative methyltransferase domains that modify chromatin and regulate cellular transcription.
• Some family members, PRMT1 and PRMT4, show transcriptional modulation and intracellular signaling.
• Through a highly conserved S-adenosylmethionine-binding domain, PRMT2 inhibits NF-kappaB-dependent transcription and promotes apoptosis.
• PRMT2 has this effect by blocking nuclear export of IkappaB-alpha through a leptomycin-sensitive pathway, which increases nuclear IkappaB-alpha and decreases NF-kappaB DNA binding.
• PRMT2 also renders cells susceptible to apoptosis by cytokines or cytotoxic drugs.
• Applications:Suitable for use in Western Blot, Immunohistochemistry.
• Other applications not tested.
• Recommended Dilution:Western Blot: 1:500-1:2000Immunohistochemistry: 1:50-1:200Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.