Several tumor-associated antigen families, such as MAGE, GAGE, PRAME and BAGE, are of interest in tumor immunology because their expression, with exception of testis and fetal tissues, seems to be restricted to tumor cells.
The MAGE, BAGE and GAGE genes code for distinct antigens that are recognized by autologous cytolytic T lymphocytes.
Many of these antigens represent suitable targets for tumor immunotherapy because their expression in human melanoma cells is common and highly specific.
PRAMEL (preferentially expressed antigen in melanoma-like), also known as leucine-rich repeat-containing protein PRAME-like, is a 520 amino acid protein that belongs to the PRAME family.
Applications:Suitable for use in Western Blot, Immunohistochemistry.
Other applications not tested.
Recommended Dilution:Western Blot: 1:500-1:2000Immunohistochemistry: 1:50-1:200Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：50ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid PBS, 0.1% sodium azide, 50% glycerol.
Specificity：Recognizes endogenous levels of PRAME. Species Crossreactivity: Human
