84-2383-73　［取扱停止］PPM1D (p53 induced Protein Phosphatase 1, p53-induced Protein Phosphatase 1, PP2C delta, PP2C-delta, PP2CD, Ppm1d, PPM1D_HUMAN, Protein Phosphatase 1D, Protein Phosphatase 1D magnesium-Dependent delta Isoform, Protein Phosphatase 2C delta Isoform, Protein Phosphatase 2C Isoform delta, Protein Phosphatase magnesium Dependent 1 delta, Protein Phosphatase magnesium-D ...　225200

特徴

• Several major serine/threonine protein phosphatases have been identified in eukaryotic cells.
• These include protein phosphatase families 1, 2A, 2B, 2C, X and y (PP-1, PP-2A, PP-2B, PP-2C, PP-X and PP-y).
• These enzymes can be distinguished by their action on phosphorylase kinase and their sensitivity to certain activators and inhibitors.
• Wip1 (wildtype p53-induced phosphatase or PPM1D), a protein identified in the p53 DNA response pathway, is a member of the PP-2C family.
• Wip1 is a serine/threonine protein phosphatase which selectively inactivates p38 MAPK and dephosphorylates the ATM/ATR targets, Chk1 and p53.
• Wip1 is ubiquitously expressed but is present at very high levels in testis.
• Deletion of Wip1 results in a reduction of T and B cell function and compromised cell division, rendering cells resistant to becoming cancerous and slowing tumor development.
• Applications:Suitable for use in Western Blot and Immunohistochemistry.
• Other applications not tested.
• Recommended Dilutions:Western Blot: 1:500-1:2000Immunohistochemistry: 1:50-1:200Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.