84-2383-55　［取扱停止］PPAR gamma (Peroxisome Proliferator-Activated Receptor gamma, Short name=PPAR-gamma, Nuclear Receptor Subfamily 1 group C Member 3, PPARG, NR1C3, PPAR y, PPARy) 100ul　225190

特徴

• PPAR gamma is implicated in numerous diseases including obesity, diabetes, atherosclerosis and cancer.
• PPAR gamma activators include prostanoids, fatty acids, thiazolidinediones and N-(2-benzoylphenyl) tyrosine analogues.
• A key component in adipocyte differentiation and fat-specific gene expression, PPAR gamma may modulate macrophage functions such as proinflammatory activities, and stimulate oxidized low-density lipoprotein (x-LDL) uptake.
• A Pro12Ala polymorphism of the PPAR gamma2 gene has been reported to reduce transactivation activity in vitro.
• This substitution may affect the immune response to ox-LDL and be associated with type 2 diabetes.
• In addition, the Pro12Ala variant of the PPAR gamma2 gene maybe correlated with abdominal obesity in type 2 diabetes.
• Applications:Suitable for use in Western Blot.
• Other applications not tested.
• Recommended Dilution:Western Blot: 1:500-1:1000Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.