84-2383-35　［取扱停止］POM121 (Nuclear Envelope Pore Membrane Protein POM 121, Nuclear Envelope Pore Membrane Protein POM 121A, Nucleoporin Nup121, Pore Membrane Protein of 121kD, POM121, KIAA0618, NUP121, POM121A, Putative Nuclear Envelope Pore Membrane Protein POM 121B, POM121B, Nuclear Envelope Pore Membrane Protein POM 121C, Nuclear Pore Membrane Protein 121-2, POM121-2, Pore Membra ...　225180

特徴

• POM121 (POM121 membrane glycoprotein), also known as POM121A (nuclear envelope pore membrane protein POM 121A), NUP121 (nucleoporin Nup121) or pore membrane protein of 121 kDa, is a 1,249 amino acid single-pass membrane protein that exists as three alternatively spiced isoforms and belongs to the POM121 family.
• Encoded by a gene that maps to human chromosome 7q11.23, POM121 is highly conserved and localizes to nucleus membrane and endoplasmic reticulum membrane.
• An essential component of the nuclear pore complex (NPC), POM121 is mandatory for nuclear envelope formation and may play a role in biogenesis of the NPC.
• POM121 associates with the central spoke ring complex and is involved in anchoring components of the pore complex to the pore membrane by way of its F-X-F-G repeat-containing domain.
• POM121 overexpression induces the formation of cytoplasmic annulate lamellae (AL).
• Applications:Suitable for use in Western Blot, Immunohistochemistry.
• Other applications not tested.
• Recommended Dilution:Western Blot: 1:500-1:1000Immunohistochemistry: 1:50-1:200Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.