The Adiponutrin family members, which have been implicated in obesity and diabetes, consist of Adiponutrin (ADPN), GS1, GS2, GS2-like, PNPLA1, and adipose triglyceride lipase (ATGL), also designated Desnutrin or Patatin-like phospholipase domain-containing protein 2 (PLNPA2).
AGTL is a 486-amino acid protein that is highly expressed in mouse and human adipose tissue.
It contains a highly conserved 180-amino acid N-terminal patatin domain common to plant acyl-hydrolases with a glycine-rich region, an aspartate active site motif, and an active serine hydrolase motif.
Along with hormone-sensitive lipase, ATGL catabolizes stored triglycerides in mammalian adipose tissue.
The lipase activity of AGTL is dependent upon the presence of an activated serine residue.
ADPN and ATGL are oppositely regulated by insulin, where upregulation of ATGl and downregulation of ADPN occurs when fasting.
Applications:Suitable for use in Western Blot, Immunohistochemistry.
Other applications not tested.
Recommended Dilution:Western Blot: 1:500-1:2000Immunohistochemistry: 1:50-1:200Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：50ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid PBS, 0.1% sodium azide, 50% glycerol.
Specificity：Recognizes endogenous levels of PNPLA2. Species Crossreactivity: Human, mouse, rat
Isotype：IgG
Calc Applications Abbrev：IHC WB
Calc Crossreactivity：Hu Mo Rt
Immunogen：Recombinant full length Human PNPLA2.
Shelf Life：1year
Swiss Prot Number：Q96AD5
EU Commodity Code：30021010
商品名：PNPLA2 (Adipose triglyceride Lipase, ATGL, ATGL DESNUTRIN, Calcium independent phosphoLipase A2, Calcium-independent phosphoLipase A2, Desnutrin, FP17548, IPLA2 zeta, IPLA2-zeta, PATATIN LIKE PHOSPHOLipase Domain Containing Protein 2, Patatin-like phosphoLipase Domain-Containing Protein 2, PEDF R, PHOSPHOLipase A2 Calcium INDEPENDENT ZETA, Pigment epithelium derived Factor, Pigment epithelium-derived Factor, plpl, plpl2, PLPL2_HUMAN, Pnpla2, Transport secretion Protein 2, Transport secretion Protein 2.2, Transport-secretion Protein 2, Triglyceride Hydrolase, TTS 2.2, TTS2, TTS2.2, ZETA,) 50ul
