84-2382-57　［取扱停止］PLK1 (Serine/threonine-Protein Kinase PLK1, Polo-like Kinase 1, PLK-1, Serine/threonine-Protein Kinase 13, STPK13, PLK1, PLK) 50ul　225141

特徴

• PLK1 (polo-like kinase 1) is a member of the serine/threonine protein kinase family, cdc5/polo subfamily.
• PLK1 contains two polo box domains with a predicted molecular weight of 68 kDa.
• PLK1 has been shown to regulate cdc2/cyclin B through phosphorylation and activation of cdc25c phosphatase.
• PLK1 is modified by phosphorylation at Threonine 210.
• PLK1 may also be required for cell division.
• Depletion of PLK1 results in apoptosis and deregulation of expression of PKL1 is correlated with development of many malignancies.
• Studies have shown that ab14209 preferentially detects the kinetochore-associated pool of Plk1.
• An alternative antibody, Mouse monoclonal to Plk1 (ab14210) preferentially stains centrosomal-associated Plk1.
• Applications:Suitable for use in Western Blot, Immunohistochemistry.
• Other applications not tested.
• Recommended Dilution:Western Blot: 1:500-1:2000Immunohistochemistry: 1:50-1:200Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.