84-2380-69　［取扱停止］PITPNB (Phosphatidylinositol transfer Protein beta Isoform, PI-TP-beta, PtdIns transfer Protein beta, PtdInsTP beta, PITPbeta, PI-TPbeta, PI-TP-beta) 50ul　225048

特徴

• The lipid binding proteins known as phosphatidylinositol transfer proteins (PITP) facilitate the formation of phosphatidylinositol derived second messenger molecules, which are related to the phospholipase C and phosphoinositide 3-kinase pathways.
• PITP are ubiquitously expressed proteins that transfer phosphatidylinositol (PI) and phosphatidylcholine (PC) between membranes enriched in PI or PC to membranes that are deficient in PI or PC.
• PITP mobilizes PI from the endoplasmic recticulum and regulates the release of PI from stored vesicles in the Golgi network.
• In mammalian cells, three smaller forms of soluble PITP are present, designated PITPalpha, PITPbeta and retinal degeneration B (rdgB) beta.
• PITPbeta is a 271 amino acid protein that is widely expressed in various tissues.
• Though required for Golgi targeting, constitutive phosphorylation of Ser-262 has no effect on phospholipid transfer activity.
• There are two isoforms of PITPbeta that are produced as a result of alternative splicing events.
• Applications:Suitable for use in Western Blot.
• Other applications not tested.
• Recommended Dilution:Western Blot: 1:500-1:1000Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.