84-2380-47　［取扱停止］PIGA (Class A GlcNAc inositol Phospholipid assembly Protein, GlcNAc PI synthesis Protein, GlcNAc-PI synthesis Protein, GPI3, MCAHS2, Phosphatidylinositol glycan anchor biosynthesis class A, phosphatidylinositol glycan anchor biosynthesis, class A (paroxysmal nocturnal hemoglobinuria), Phosphatidylinositol glycan biosynthesis class A Protein, Phosphatidylinositol N ...　225037

特徴

• Phosphatidylinositol-glycans (PIGs) are multi-pass transmembrane proteins that localize to the endoplasmic reticulum.
• PIGs are crucial for the synthesis of N-acetylglucosaminyl-phosphatidylinositol (GlcNAc-PI), a very early intermediate in glycosylphosphatidylinositol (GPI)-anchor biosynthesis.
• The PIG proteins are components of the GPI transamidase complex and play a role in the recognition of either the GPI attachment signal or the lipid portion of GPI.
• Phospha-tidylinositol glycan class A (PIG-A), an endoplasmic reticulum (ER) transmembrane protein, contains a large cytoplasmic domain, which displays homology to the bacterial GlcNAc transferase RfaK, and a small lumenal domain, which plays a role in targeting the PIG-A protein to the rough ER.
• PIG-A associates with PIG-C, PIG-H, PIG-P and PIG-Q, as well as DPM2, and interacts directly with PIG-y.
• Defects in PIG-A cause paroxysmal nocturnal hemoglobinuria (PNH), an acquired genetic hematologic disorder.
• Applications:Suitable for use in Western Blot, Immunohistochemistry.
• Other applications not tested.
• Recommended Dilution:Western Blot: 1:500-1:2000Immunohistochemistry: 1:50-1:200Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.