84-2379-92　［取扱停止］PI3 (Cementoin, ELAF_HUMAN, Elafin, Elastase Specific Inhibitor, Elastase-specific Inhibitor, ES 1, ESI, Peptidase Inhibitor 3, Peptidase Inhibitor 3, Skin derived, PI 3, PI-3, PI3, Pre elafin, Protease Inhibitor 3 Skin derived, Protease Inhibitor 3, Skin derived (SKALP), Protease Inhibitor WAP3, SKALP, Skin derived Anti leukoProteinase, Skin-derived antileukoProt ...　225010

特徴

• Elafin, also known as elastase-specific inhibitor (ESI) or skin-derived anti-leukoproteinase (SKALP), is a low molecular weight elastase inhibitor derived from psoriatic skin.
• Elafin is found in the epidermis of several inflammatory skin diseases, but not in normal human epidermis.
• It is found in the urine of psoriatic patients, and immunohistochemical studies show that elafin is found in the suprabasal differentiated keratinocytes of psoriatic epidermis.
• In inflamed skin, elafin exists both as a free form and as an immobilized form covalently attached to the cornified envelopes by transglutaminase cross-linking.
• Although there is no allelic association between pustular psoriasis (or psoriasis in general) and polymorphism of the PI3 gene, a decrease of elafin is found in lesional skin of patients with pustular psoriasis compared with plaque-type psoriasis.
• Applications:Suitable for use in Western Blot and Immunohistochemistry.
• Other applications not tested.
• Recommended Dilution:Western Blot: 1:500-1:2000Immunohistochemistry: 1:50-1:200Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.