TSSC3 (Tumor-suppressing STF cDNA 3 protein), also known as PHLDA2 (pleckstrin homology-like domain family A member 2), BWR1C, HLDA2 or IPL, is a cytoplasmic protein that is involved in fetal and placental growth.
Expressed at high levels in placenta and adult prostate and at low levels in liver, lung and brain, TSSC3 is an apoptosis-related protein that acts as a negative growth regulator and is expressed during normal human development.
TSSC3, a protein expressed from the maternal allele, is imprinted on placenta, liver and fetal tissues during embryogenesis and is removed once development is complete.
Defects or alterations in the gene encoding TSSC3 are associated with several afflictions such as lung, ovarian and breast cancer, rhabdomyosarcoma, Beckwith-Wiedemann syndrome, Wilms tumor, low birth weight and adrenocortical carcinoma.
Applications:Suitable for use in Western Blot, Immunohistochemistry.
Other applications not tested.
Recommended Dilution:Western Blot: 1:500-1:2000Immunohistochemistry: 1:50-1:200Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid PBS, 0.1% sodium azide, 50% glycerol.
Specificity：Recognizes endogenous levels of PHLDA2. Species Crossreactivity: Human
Isotype：IgG
Calc Applications Abbrev：IHC WB
Calc Crossreactivity：Hu
Immunogen：Recombinant full length Human PHLDA2.
Shelf Life：1year
Swiss Prot Number：Q53GA4
EU Commodity Code：30021010
商品名：PHLDA2 (Beckwith Wiedemann Syndrome Chromosome region 1 candidate Protein C, Beckwith-Wiedemann Syndrome Chromosomal region 1 candidate Gene C Protein, BRW 1C, BRW1C, BWR 1C, BWR1C, HLDA 2, HLDA2, Imprinted in placenta and liver, Imprinted in placenta and liver Protein, IPL, IPL, p17 Beckwith Wiedemann region 1C, p17 BWR1C, p17-Beckwith-Wiedemann region 1 C, p17-BWR1C, PHLA2_HUMAN, PHLDA 2, phlda2, Pleckstrin Homology like Domain Family A Member 2, Pleckstrin Homology-like Domain Family A Member 2, TSSC 3, Tumor suppressing STF cDNA 3 Protein, Tumor suppressing subChromosomal transferable fragment candidate Gene 3 Protein, Tumor suppressing subChromosomal transferable fragment cDNA 3, Tumor suppressing subtransferable candidate 3, Tumor supressing STF cDNA 3, Tumor-suppressing STF cDNA 3 Protein, Tumor-suppressing subChromosomal transferable fragment candidate Gene 3 Protein,) 100ul
