Human PGD synthase is the key enzyme for production of the D and J series of prostanoids in the immune system and mast cells.
This enzyme is the first member of the sigma class glutathione S-transferases (GST) from vertebrates and contains a prominent cleft as the active site, which is unique among members of the GST superfamily.
The human PGD synthase gene, which maps to chromosome 4q22.3, is expressed in a species-specific manner.
For instance, the human gene is widely distributed, whereas the mouse gene is only expressed in oviduct and skin.
Human PGD synthase is expressed in the cytoplasm of human megakaryoblastic CMK cells prior to differentiation into platelets, which have no PGD synthase activity.
Another member of the PGD synthase family, PGD2 synthase, catalyzes the conversion of PGH2 to PGD2 and is essential for the synthesis of PGD2 in the brain.
Unlike PGD synthase, PGD2 synthase is not dependent on the presence of glutathione for its activity.
Applications:Suitable for use in Western Blot.
Other applications not tested.
Recommended Dilution:Western Blot: 1:500-1:1000Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：50ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid PBS, 0.1% sodium azide, 50% glycerol.
Specificity：Recognizes endogenous levels of PGD synthase. Species Crossreactivity: Human, mouse, rat
Isotype：IgG
Calc Applications Abbrev：WB
Calc Crossreactivity：Hu Mo Rt
Immunogen：A synthetic peptide corresponding to residues in Human PGD synthase.
