This gene encodes a PDZ domain-containing scaffolding protein.
PDZ domain-containing molecules bind to and mediate the subcellular localization of target proteins.
The encoded protein mediates the localization of cell surface proteins and plays a critical role in cholesterol metabolism by regulating the HDL receptor, scavenger receptor class B type 1.
Single nucleotide polymorphisms in this gene may be associated with metabolic syndrome, and overexpression of this gene may play a role in drug resistance of multiple myeloma.
Pseudogenes of this gene are located on the long arm of chromosome 1.
Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
Applications:Suitable for use in Western Blot, Immunohistochemistry.
Other applications not tested.
Recommended Dilution:Western Blot: 1:500-1:2000Immunohistochemistry: 1:50-1:200Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：50ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid PBS, 0.1% sodium azide, 50% glycerol.
Specificity：Recognizes endogenous levels of PDZK1. Species Crossreactivity: Human, mouse, rat
Isotype：IgG
Calc Applications Abbrev：IHC WB
Calc Crossreactivity：Hu Mo Rt
Immunogen：Recombinant full length Human PDZK1.
Shelf Life：1year
Swiss Prot Number：Q5T2W1
EU Commodity Code：30021010
商品名：PDZK1 (1700023D20Rik, 2610507N21Rik, 4921513F16Rik, AI267131, AI314638, AL022680, C Terminal linking and modulating Protein, CAP70, CFTR Associated Protein of 70kD, CFTR Associated Protein, 70-KD, CFTR-Associated Protein of 70kD, CLAMP, D3Ertd537e, Dietary Pi-Regulated RNA-1, Diphor-1, mPDZK1, Na(+)/H(+) Exchange Regulatory CoFactor NHE-RF3, Na(+)/H(+) Exchanger Regulatory Factor 3, Na/Pi Cotransporter C-Terminal-Associated Protein 1, Na/Pi Cotransporter C-Terminal-Associated Protein, NaPi Cap1, NaPi-Cap1, NaPiCap1, NHERF 3, NHERF-3, NHERF3, NHRF3_HUMAN, OTTHUMP00000015572, PDZ Domain Containing 1, PDZ Domain Containing Protein 1, PDZ Domain-Containing Protein 1, PDZD1, PDZK1, Sodium hydrogen Exchanger Regulatory Factor 3, Sodium-hydrogen Exchanger Regulatory Factor 3,) 50ul
