The Proenkephalin precursor proteins are secreted proteins belonging to the opioid neuropeptide precursor family.
The Proenkephalin proteins are proteolytically processed to form active secreted opioid peptides, which function as ligands for the ˚-type of opioid receptor.
The Proenkephalin A precursor contains Synenkephalin, Leu-enkephalin and Met-enkephalin processed active peptides, while the Proenkephalin B precursor contains beta-neoendorphin, Dynorphin, Leumorphin, Leu-enkephalin and rimorphin processed active peptides.
beta-endorphin and Met-enkephalin are endogenous opiates, while ACTH is crucial for adrenal gland stimulation to release cortisol.
MSH increases melanin production in melanocytes, which leads to an increase in skin pigmentation.
Leumorphin may be important in apoptosis prevention by being involved in the MAP kinase and PI 3-kinase pathways.
Applications:Suitable for use in Western Blot, Immunohistochemistry.
Other applications not tested.
Recommended Dilution:Western Blot: 1:500-1:2000Immunohistochemistry: 1:50-1:200Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid PBS, 0.1% sodium azide, 50% glycerol.
Specificity：Recognizes endogenous levels of PDYN. Species Crossreactivity: Human
