The protein encoded by the PDLIM5 (PDZ and LIM domain 5) gene is a LIM domain protein.
LIM domains are cysteine rich double zinc fingers composed of 50-60 amino acids that are involved in protein-protein interactions.
LIM domain containing proteins are scaffolds for the formation of multiprotein complexes.
They are involved in cytoskeleton organization, where they interact with various PKC isoforms through the LIM domains and with actin and alpha actinin through the PDZ domain.
In addition, they are involved in cell lineage specification, organ development, and oncogenesis.
This protein is also a member of the Enigma class of proteins, a family of proteins that have a 100 amino acid PDZ domain in the N terminus and 1 to 3 LIM domains in the C terminus.
Multiple transcript variants encoding different isoforms have been found for this gene, but not all of them have been fully characterized.
Applications:Suitable for use in Western Blot.
Other applications not tested.
Recommended Dilution:Western Blot: 1:500-1:1000Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：50ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid PBS, 0.05% sodium azide, pH 7.2.
Specificity：Recognizes endogenous levels of PDLIM5. Species Crossreactivity: Human
Isotype：IgG
Calc Applications Abbrev：WB
Calc Crossreactivity：Hu
Immunogen：Synthetic peptide corresponding to aa223-270 of Human PDLIM5.
