84-2378-55　［取扱停止］PDIA3 (58 a Glucose Regulated Protein, 58 a Glucose-Regulated Protein, 58 a microsomal Protein, Disulfide Isomerase ER 60, Disulfide Isomerase ER-60, Endoplasmic Reticulum resident Protein 57, Endoplasmic Reticulum resident Protein 60, ER p57, ER Protein 57, ER Protein 60, ERp 57, ERp57, ERp60, ERp61, Glucose Regulated Protein 58, GRP 57, GRP 58, GRP57, GRP58, HsT ...　224939

特徴

• Mammals defend themselves against intracellular pathogens through presentation of cytoplasmically-derived short pathogenic peptides to the cell surface of cytotoxic T lymphocytes, which subsequently leads to cytotoxic events with respect to the affected cell.
• Antigen presentation is mediated by major histocompatibility complex (MHC) class I molecules, which bind and coordinate short pathogenic peptides.
• MHC class I molecules assemble in the endoplasmic reticulum with chaperones before binding to the transporter associated with antigen processing (TAP).
• ERp57, also designated GRP57, GRP58, ERp60 and ERp61, is a component of the MHC class I pathway that appears to interact with MHC class I molecules before they associate with TAP.
• The human ERp57 gene maps to chromosome 15q15 and encodes a 505 amino acid protein.
• ERp57 has two Trp-Cys-Gly-His-Cys-Lys motifs completely conserved among the mammals.
• ERp57 may act as a protease, a protein disulfide isomerase, a phospholipase or a combination of these.
• Applications:Suitable for use in Immunofluorescence, Western Blot and Immunohistochemistry.
• Other applications not tested.
• Recommended Dilution:Western Blot: 1:500-1:2000Immunohistochemistry (Paraffin): 1:50-1:100Immunofluorescence: 1:50-1:100Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.