84-2378-21 ［取扱停止］PDE4D (cAMP-specific 3',5'-cyclic phosphodiesterase 4D, DPDE3, PDE43, PDE4D, DPDE3) 50ul 224922
特徴
- Phosphodiesterases (PDE) hydrolyze cAMP to 5’AMP and thus play a critical role in the regulation of intracellular cAMP.
- Division of the PDE superfamily by sequence homology and enzymatic properties yields 11 PDE families.
- A unique upstream conserved region (UCR) characterizes the PDE4 family.
- Four separate genes (A-D) encode the PDE4 enzymes, and alternative splicing generates short or long isoforms of each gene.
- Long PDE4 isoforms contain both UCR1 and UCR2 while short PDE4 isoforms possess only UCR2.
- Both UCR domains are necessary for dimerization of PDE4 isoforms.
- The human PDE4D gene maps to chromosome 5q11.2.
- The splice variants include isoforms PDE4D1-6.
- Applications:Suitable for use in Western Blot, Immunohistochemistry.
- Other applications not tested.
- Recommended Dilution:Western Blot: 1:500-1:2000Immunohistochemistry: 1:50-1:200Optimal dilutions to be determined by the researcher.
- Storage and Stability:May be stored at 4°C for short-term only.
- Aliquot to avoid repeated freezing and thawing.
- Store at -20°C.
- Aliquots are stable for 12 months after receipt.
- For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
- Size：50ul
- Host：rabbit
- Source Antibody：human
- Grade：Affinity Purified
- Purity：Purified by immunoaffinity chromatography.
- Form：Supplied as a liquid PBS, 0.1% sodium azide, 50% glycerol.
- Specificity：Recognizes endogenous levels of PDE4D. Species Crossreactivity: Human, mouse, rat
- Isotype：IgG
- Calc Applications Abbrev：IHC WB
- Calc Crossreactivity：Hu Mo Rt
- Immunogen：Recombinant full length Human PDE4D.
- Shelf Life：1year
- Swiss Prot Number：Q08499
- EU Commodity Code：30021010
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